increased il-17a but decreased il-27 serum levels in patients with multiple sclerosis

نویسندگان

zohreh babaloo

department of immunology, faculty of medicine reza khajir yeganeh

department of immunology, faculty of medicine mehdi farhoodi

neuroscience research center behzad baradaran

department of immunology, faculty of medicine mohamadreza bonyadi

چکیده

background: effector cd4+ t cell subsets play an important role in multiple sclerosis (ms). interleukin-27 (il-27) suppresses th (th1, th2 and th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of type 1 regulatory t cells (tr1). objective: to identify the relative levels of il-27 and il-17a in ms disease. method: in a case-control study, venous blood was collected from forty ms patients and forty-three healthy subjects as control group. serum levels of il-27 and il-17a were measured by elisa method. results: a significant difference between serum il-17a concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. serum il-27 levels of the ms patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001). conclusion: our findings show decreased levels of il-27 against increasing il-17a levels in patients group which may suggest the suppressive role of il-27 on inflammatory process of ms.

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عنوان ژورنال:
iranian journal of immunology

جلد ۱۰، شماره ۱، صفحات ۴۷-۵۴

کلمات کلیدی
[ ' i n t e r l e u k i n ' , 2 7 , ' i n t e r l e u k i n ' , ' 1 7 a ' , ' m u l t i p l e s c l e r o s i s ' ]

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